On-Body Subcutaneous Injection Systems


As drug developers widen the therapeutic envelope to create effective treatments for intractable disease targets, they are finding it necessary to move beyond traditional limits on drug formulation and dosing. Capabilities such as compact device designs, flexible cannula insertion, variable dosing and drug cartridge replacement have positioned these devices squarely within the home healthcare space. Ease-of-use features such as intuitive infusion activation, strategic button placement, digital displays and tactile feedback cues further enhance the feeling of assurance and wellbeing among users. This report describes the numerous factors that constitute a successful on-body subcutaneous injection device.




Packaging for on-body injection devices is a convergence of several technologies packaged into a footprint small and light enough to be worn by the patient using pressure sensitive adhesive. Since existing infusibles are typically supplied in vials or IV containers, often as concentrates for dilution or as lyophilized powders, the transition from caregiver administration to self-administration requires device designers and drug developers to adapt as-supplied packaging to accommodate the om-body primary container. For powder drugs, formulators are often challenged to create a solution version of the drug. If this is not an attractive option, the device designer is called upon to simplify the reconstitution step and integrate it as seamlessly as possible into the overall device operational envelope.