Inhaled drug delivery and inhaler technology

Advances in drug formulation and inhalation device design are creating new opportunities for inhaled drug delivery as an alternative to oral and parenteral delivery methods. Much of the interest in pulmonary delivery of systemic drug therapies is focused on chronic diseases and refractory conditions – aliments that require frequent drug administration for a protracted period of time. The role of device design and development in defining and driving emerging opportunities in this sector cannot be overstated. Nebulizers, metered dose inhalers (MDIs), and dry powder inhalers (DPIs) have each found a niche in the quest for optimal treatment and convenient use. While nebulizers have evolved relatively independently of the drug formulations they deliver, the current generation of MDIs and DPIs have been developed or tailored for the specific pharmaceutical being delivered, resulting in improved performance. Several of the emerging drug products covered in this report will have a significant impact in the therapeutic markets they target, improving patient compliance and effectively changing the way important illnesses and conditions are treated.

Publication Date: August 2009

Summary of Contents (See Prospectus for Full Contents)

Executive Summary

Inhaled Drug Delivery Market Dynamics

Established Therapeutic Targets

Emerging Therapies

Demographics and Growth

Competing Technologies

Market Drivers

Factors Limiting Growth

Inhalation Technology & Product Development Factors

Drug Formulations

Formulation Technologies

Delivery Profiles and Risk Factors

Excipients and Release Profiles

Inhalation Device Design Factors

Dry Powder Inhalers

Metered Dose Inhalers

Nebulizers

Performance Factors

Bioavailability

Dose Reproducibility

Active Compound Stability

Combination Drug Inhalers

Testing and Packaging

Emerging Device Technologies

Inhalation Devices – Device Assessments and Product Strategies

Dry Powder inhalers

Commercial Devices

Discrete Dose Devices

Reservoir Devices

Proprietary Dosing Technologies

Development-stage DPI Devices

Market Data and Forecasts

Metered Dose Inhalers

Commercial Devices

Pressurized MDIs

Breath-actuated MDIs

Advanced Design MDIs

Recent Technology Developments

Market Data and Forecasts

Nebulizers

Commercial Devices

Compressed Air Nebulizers

Ultrasonic Nebulizers

Advanced Technology Nebulizers

Recent Developments

Market Data and Forecasts

Inhaled Drug Delivery - Evolving Therapies, Products and Players

Upper Respiratory Indications

Asthma

Therapeutic Segment Analysis

Competitive Landscape

Prescribing Trends and Growth Factors

Emerging Inhaled Therapies

COPD

Therapeutic Segment Analysis

Competitive Landscape

Prescribing Trends and Growth Factors

Emerging Inhaled Therapies

Systemic Drug Delivery

Alpha-1 Deficiency

Bioterror

Cystic Fibrosis

Diabetes

Pulmonary Hypertension

Immune System Modulators

Infectious Diseases

Influenza

Multiple Sclerosis

Neurology

Insomnia

Migraine

Parkinson’s Disease

Schizophrenia

Oncology

Pain Management

Sexual Health

Female Sexual Dysfunction

Erectile Dysfunction

Market Factors

Usability and Patient Preferences

Regulatory Issues

Patient Compliance

The Role of CMOs/CSOs

Company Profiles

Detailed Profiles of Market Sector Participants

About Our Reports

Our reports are carefully researched and written to provide timely and insightful analysis of key factors and developments shaping the commercial marketplace. The focused nature of our publications is designed to allow readers to identify emerging demand and growth opportunities in selected markets. Numerous charts, tables and graphs complement the text, with evaluations and assessments of current and probable future market developments, technology issues and business factors - information necessary to compete effectively in the global marketplace.