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 Drug Delivery: Inhaled Drug Therapeutics

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Delivering Drugs by Inhalation
 

Advances in drug formulation and inhalation device design are creating new opportunities for inhaled drug delivery as an alternative to oral and parenteral delivery methods. Much of the interest in pulmonary delivery of systemic drug therapies is focused on chronic diseases and refractory conditions – aliments that require frequent drug administration for a protracted period of time. The role of device design and development in defining and driving emerging opportunities in this sector cannot be overstated. Nebulizers, metered dose inhalers (MDIs), and dry powder inhalers (DPIs) have each found a niche in the quest for optimal treatment and convenient use. While nebulizers have evolved relatively independently of the drug formulations they deliver, the current generation of MDIs and DPIs have been developed or tailored for the specific pharmaceutical being delivered, resulting in improved performance. Several of the emerging drug products covered in this report will have a significant impact in the therapeutic markets they target, improving patient compliance and effectively changing the way important illnesses and conditions are treated.

Publication Date: May 2008

Table of Contents

 

Executive Summary

 

Inhaled Drug Delivery Market Dynamics

 

Portrait of an Evolving Market

Established Therapeutic Targets

Emerging Therapies

Demographics and Growth

Competing Technologies

Market Drivers

Factors Limiting Growth

Inhalation Technology

 

Drug Formulations

Inhaler Designs

    Dry Powder Inhalers

    Metered Dose Inhalers

    Nebulizers

Performance Factors

    Bioavailability

    Dose Reproducibility

    Active Compound Stability

Commercial Devices

Development-Stage Devices

Combination Products

Emerging Device Technologies

 

 

Inhaled Drugs – Development-stage Product Candidates

 

Anaphylaxis

Cardiovascular Medicine

Hereditary Diseases

Immunology

Infectious Diseases

Metabolic

    Growth Deficiencies

    Osteoporosis

Neurology

    Antipsychotics

    Migraine

    Parkinson’s

Oncology

Pain Management

Respiratory

Sexual Health

 

 

Market Factors

 

Device Packaging

Regulatory Issues

Patient Compliance

The Role of CMOs/CSOs

Healthcare Economics

 

Company Profiles

 

Detailed Profiles of Market Sector Participants

 

About Our Reports

Our reports are carefully researched and written to provide timely and insightful analysis of key factors and developments shaping the commercial marketplace. The focused nature of our publications is designed to allow readers to identify emerging demand and growth opportunities in selected markets. Numerous charts, tables and graphs complement the text, with evaluations and assessments of current and probable future market developments, technology issues and business factors - information necessary to compete effectively in the global marketplace.